Autoantibodies to glutamate receptor GluR3 in Rasmussen's encephalitis.


Journal Article

Rasmussen's encephalitis is a progressive childhood disease of unknown cause characterized by severe epilepsy, hemiplegia, dementia, and inflammation of the brain. During efforts to raise antibodies to recombinant glutamate receptors (GluRs), behaviors typical of seizures and histopathologic features mimicking Rasmussen's encephalitis were found in two rabbits immunized with GluR3 protein. A correlation was found between the presence of Rasmussen's encephalitis and serum antibodies to GluR3 detected by protein immunoblot analysis and by immunoreactivity to transfected cells expressing GluR3. Repeated plasma exchanges in one seriously ill child transiently reduced serum titers of GluR3 antibodies, decreased seizure frequency, and improved neurologic function. Thus, GluR3 is an autoantigen in Rasmussen's encephalitis, and an autoimmune process may underlie this disease.

Full Text

Duke Authors

Cited Authors

  • Rogers, SW; Andrews, PI; Gahring, LC; Whisenand, T; Cauley, K; Crain, B; Hughes, TE; Heinemann, SF; McNamara, JO

Published Date

  • July 29, 1994

Published In

Volume / Issue

  • 265 / 5172

Start / End Page

  • 648 - 651

PubMed ID

  • 8036512

Pubmed Central ID

  • 8036512

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.8036512


  • eng

Conference Location

  • United States