Excitatory amino acid receptors in epilepsy.


Journal Article (Review)

Excitatory amino acid transmitters participate in normal synaptic transmission throughout the CNS (see Headley and Grillner, May TiPS), so it comes as no surprise that such excitatory pathways are involved in the initiation of seizures and their propagation. Most attention has been directed to synapses using NMDA receptors, although more recent evidence indicates potential roles for the AMPA receptors as well. In this article--the first of two to focus on the neurological dangers inherent in excitatory amino acid pathways--Raymond Dingledine, Chris McBain and James McNamara consider their involvement in epilepsy; next month's article will cover brain damage following ischemia and hypoxia.

Full Text

Duke Authors

Cited Authors

  • Dingledine, R; McBain, CJ; McNamara, JO

Published Date

  • August 1990

Published In

Volume / Issue

  • 11 / 8

Start / End Page

  • 334 - 338

PubMed ID

  • 2168104

Pubmed Central ID

  • 2168104

International Standard Serial Number (ISSN)

  • 0165-6147

Digital Object Identifier (DOI)

  • 10.1016/0165-6147(90)90238-4


  • eng

Conference Location

  • England