Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission.
Journal Article (Journal Article)
Intranigral gamma-vinyl-GABA (GVG) suppresses electroshock seizures (ES). This anticonvulsant action was blocked by systemic treatment with the alpha 2-antagonist idazoxan. Consequently, we tested the idea that intranigral GABA mimetics suppress ES by increasing noradrenergic (NE) neuronal activity. Contrary to our hypothesis, GVG decreased NE turnover. This result indicates that while the seizure-suppressant effect of intranigral GVG requires alpha 2-mediated NE neurotransmission, the mechanism of this anticonvulsant action is not by increasing NE neuronal activity.
Full Text
Duke Authors
Cited Authors
- Bonhaus, DW; McNamara, JO
Published Date
- January 12, 1988
Published In
Volume / Issue
- 438 / 1-2
Start / End Page
- 391 - 394
PubMed ID
- 2830944
International Standard Serial Number (ISSN)
- 0006-8993
Digital Object Identifier (DOI)
- 10.1016/0006-8993(88)91370-4
Language
- eng
Conference Location
- Netherlands