Anticonvulsant action of intranigral gamma-vinyl-GABA: role of nonadrenergic neurotransmission.

Journal Article (Journal Article)

Intranigral gamma-vinyl-GABA (GVG) suppresses electroshock seizures (ES). This anticonvulsant action was blocked by systemic treatment with the alpha 2-antagonist idazoxan. Consequently, we tested the idea that intranigral GABA mimetics suppress ES by increasing noradrenergic (NE) neuronal activity. Contrary to our hypothesis, GVG decreased NE turnover. This result indicates that while the seizure-suppressant effect of intranigral GVG requires alpha 2-mediated NE neurotransmission, the mechanism of this anticonvulsant action is not by increasing NE neuronal activity.

Full Text

Duke Authors

Cited Authors

  • Bonhaus, DW; McNamara, JO

Published Date

  • January 12, 1988

Published In

Volume / Issue

  • 438 / 1-2

Start / End Page

  • 391 - 394

PubMed ID

  • 2830944

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(88)91370-4


  • eng

Conference Location

  • Netherlands