Microinjection of muscimol into entopeduncular nucleus suppresses pilocarpine but not maximal electroshock seizures in rats.

Journal Article (Journal Article)

Microinjection of muscimol (406 pmol) into the rat entopeduncular nucleus, the analogue of the primate globus pallidus pars interna, significantly suppressed pilocarpine but not maximal electroshock seizures in a spatially specific manner. In contrast to its lack of efficacy in the entopeduncular nucleus, microinjection of muscimol into the substantia nigra suppressed maximal electroshock seizures. These findings suggest that the neural networks and/or the neurotransmitters that subserve the propagation of pilocarpine and maximal electroshock seizures differ with regard to the entopeduncular nucleus. The data also underscore the powerful regulatory role of the substantia nigra in diverse models of seizures.

Full Text

Duke Authors

Cited Authors

  • Hosford, DA; McNamara, JO

Published Date

  • October 18, 1988

Published In

Volume / Issue

  • 462 / 2

Start / End Page

  • 205 - 210

PubMed ID

  • 3191383

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(88)90548-3


  • eng

Conference Location

  • Netherlands