Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol.

Published

Journal Article

The effects of systemically administered catecholamine receptor antagonists on the anticonvulsant action produced by local application of a gamma-aminobutyric acid agonist, muscimol, to the substantia nigra of rats were studied. Both electroshock and kindled seizures were studied. Two alpha-2 receptor antagonists, idazoxan and yohimbine, blocked the anticonvulsant action of intranigral muscimol in the electroshock model. Neither a beta nor an alpha-1 adrenergic nor a dopamine-2 receptor antagonist blocked this action. In contrast to electroshock seizures, an alpha-2 antagonist only partially reversed the anticonvulsant action of intranigral muscimol in the kindling model. We interpret the data to indicate that the interaction of norepinephrine with alpha-2 receptors is required for the anticonvulsant action of intranigral muscimol in the electroshock model. The only partial reversal found in the kindling model suggests that nigral control of seizure propagation involves more than alpha-2 receptor mediated neurotransmission.

Full Text

Duke Authors

Cited Authors

  • Platt, K; Butler, LS; Bonhaus, DW; McNamara, JO

Published Date

  • June 1, 1987

Published In

Volume / Issue

  • 241 / 3

Start / End Page

  • 751 - 754

PubMed ID

  • 3037068

Pubmed Central ID

  • 3037068

International Standard Serial Number (ISSN)

  • 0022-3565

Language

  • eng

Conference Location

  • United States