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Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol.

Publication ,  Journal Article
Platt, K; Butler, LS; Bonhaus, DW; McNamara, JO
Published in: J Pharmacol Exp Ther
June 1987

The effects of systemically administered catecholamine receptor antagonists on the anticonvulsant action produced by local application of a gamma-aminobutyric acid agonist, muscimol, to the substantia nigra of rats were studied. Both electroshock and kindled seizures were studied. Two alpha-2 receptor antagonists, idazoxan and yohimbine, blocked the anticonvulsant action of intranigral muscimol in the electroshock model. Neither a beta nor an alpha-1 adrenergic nor a dopamine-2 receptor antagonist blocked this action. In contrast to electroshock seizures, an alpha-2 antagonist only partially reversed the anticonvulsant action of intranigral muscimol in the kindling model. We interpret the data to indicate that the interaction of norepinephrine with alpha-2 receptors is required for the anticonvulsant action of intranigral muscimol in the electroshock model. The only partial reversal found in the kindling model suggests that nigral control of seizure propagation involves more than alpha-2 receptor mediated neurotransmission.

Duke Scholars

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

June 1987

Volume

241

Issue

3

Start / End Page

751 / 754

Location

United States

Related Subject Headings

  • Substantia Nigra
  • Seizures
  • Receptors, Adrenergic, alpha
  • Rats, Inbred Strains
  • Rats
  • Pharmacology & Pharmacy
  • Muscimol
  • Microinjections
  • Male
  • Kindling, Neurologic
 

Citation

APA
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ICMJE
MLA
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Platt, K., Butler, L. S., Bonhaus, D. W., & McNamara, J. O. (1987). Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol. J Pharmacol Exp Ther, 241(3), 751–754.
Platt, K., L. S. Butler, D. W. Bonhaus, and J. O. McNamara. “Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol.J Pharmacol Exp Ther 241, no. 3 (June 1987): 751–54.
Platt K, Butler LS, Bonhaus DW, McNamara JO. Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol. J Pharmacol Exp Ther. 1987 Jun;241(3):751–4.
Platt, K., et al. “Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol.J Pharmacol Exp Ther, vol. 241, no. 3, June 1987, pp. 751–54.
Platt K, Butler LS, Bonhaus DW, McNamara JO. Evidence implicating alpha-2 adrenergic receptors in the anticonvulsant action of intranigral muscimol. J Pharmacol Exp Ther. 1987 Jun;241(3):751–754.

Published In

J Pharmacol Exp Ther

ISSN

0022-3565

Publication Date

June 1987

Volume

241

Issue

3

Start / End Page

751 / 754

Location

United States

Related Subject Headings

  • Substantia Nigra
  • Seizures
  • Receptors, Adrenergic, alpha
  • Rats, Inbred Strains
  • Rats
  • Pharmacology & Pharmacy
  • Muscimol
  • Microinjections
  • Male
  • Kindling, Neurologic