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The role of substantia nigra in the development of kindling: pharmacologic and lesion studies.

Publication ,  Journal Article
Shin, C; Silver, JM; Bonhaus, DW; McNamara, JO
Published in: Brain Res
June 2, 1987

The role of substantia nigra (SN) in the development of kindling was investigated. Microinjection of gamma-vinyl gamma-aminobutyric acid (GVG), a gamma-aminobutyric acid (GABA) transaminase inhibitor, into the SN bilaterally retarded kindling development by 77%. GVG injected dorsal to the SN did not alter the kindling rate. By contrast, lesions of the SN, whether by thermocoagulation or by microinjected neurotoxin, N-methyl-D,L-aspartate, facilitated kindling development by 27-44%. Thermocoagulative lesions dorsal to the SN did not affect the rate of kindling development. Thus these two manipulations, each presumed to suppress the activity of the SN, resulted in opposite effects on kindling development. We interpret the pharmacologic findings to indicate that the intact SN can powerfully facilitate kindling development. However, the SN is not vital for kindling development, since kindling can be established after destruction of a considerable portion of SN. Whether the increased rate of kindling development following SN lesions is due solely to the absence of SN remains unclear.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

June 2, 1987

Volume

412

Issue

2

Start / End Page

311 / 317

Location

Netherlands

Related Subject Headings

  • Vigabatrin
  • Substantia Nigra
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • N-Methylaspartate
  • Male
  • Kindling, Neurologic
  • Aspartic Acid
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shin, C., Silver, J. M., Bonhaus, D. W., & McNamara, J. O. (1987). The role of substantia nigra in the development of kindling: pharmacologic and lesion studies. Brain Res, 412(2), 311–317. https://doi.org/10.1016/0006-8993(87)91138-3
Shin, C., J. M. Silver, D. W. Bonhaus, and J. O. McNamara. “The role of substantia nigra in the development of kindling: pharmacologic and lesion studies.Brain Res 412, no. 2 (June 2, 1987): 311–17. https://doi.org/10.1016/0006-8993(87)91138-3.
Shin C, Silver JM, Bonhaus DW, McNamara JO. The role of substantia nigra in the development of kindling: pharmacologic and lesion studies. Brain Res. 1987 Jun 2;412(2):311–7.
Shin, C., et al. “The role of substantia nigra in the development of kindling: pharmacologic and lesion studies.Brain Res, vol. 412, no. 2, June 1987, pp. 311–17. Pubmed, doi:10.1016/0006-8993(87)91138-3.
Shin C, Silver JM, Bonhaus DW, McNamara JO. The role of substantia nigra in the development of kindling: pharmacologic and lesion studies. Brain Res. 1987 Jun 2;412(2):311–317.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

June 2, 1987

Volume

412

Issue

2

Start / End Page

311 / 317

Location

Netherlands

Related Subject Headings

  • Vigabatrin
  • Substantia Nigra
  • Rats, Inbred Strains
  • Rats
  • Neurology & Neurosurgery
  • N-Methylaspartate
  • Male
  • Kindling, Neurologic
  • Aspartic Acid
  • Animals