Scholars@Duke publication: Intranigral dynorphin-1-13 suppresses kindled seizures by a naloxone-insensitive mechanism.

Intranigral dynorphin-1-13 suppresses kindled seizures by a naloxone-insensitive mechanism.

Publication , Journal Article

Bonhaus, DW; Rigsbee, LC; McNamara, JO

Published in: Brain Res

March 10, 1987

Numerous lines of evidence indicate that the substantia nigra (SN) facilitates the propagation of seizures in kindling and in other seizure models. Intranigral injection of dynorphin-1-13 exerted a potent seizure suppressant action in kindled rats. This seizure suppressant action was dose dependent, spatially specific for the area of the SN and was not blocked by naloxone (2 mg/kg i.p.). This finding extends previous work indicating that treatments which reduce SN output exert an anticonvulsant action and further suggests that opioid peptides endogenous to the SN may regulate seizure susceptibility in the kindling model.

Duke Scholars

Author James O'Connell McNamara Sr. Neurobiology

Published In

Brain Res

DOI

10.1016/0006-8993(87)90306-4

ISSN

0006-8993

Publication Date

March 10, 1987

Volume

405

Issue

Start / End Page

358 / 363

Location

Netherlands

Related Subject Headings

Substantia Nigra
Rats, Inbred Strains
Rats
Peptide Fragments
Neurology & Neurosurgery
Naloxone
Microinjections
Male
Kindling, Neurologic
Epilepsy

Citation

APA

Chicago

ICMJE

MLA

NLM

Bonhaus, D. W., Rigsbee, L. C., & McNamara, J. O. (1987). Intranigral dynorphin-1-13 suppresses kindled seizures by a naloxone-insensitive mechanism. Brain Res, 405(2), 358–363. https://doi.org/10.1016/0006-8993(87)90306-4

Bonhaus, D. W., L. C. Rigsbee, and J. O. McNamara. “Intranigral dynorphin-1-13 suppresses kindled seizures by a naloxone-insensitive mechanism.” Brain Res 405, no. 2 (March 10, 1987): 358–63. https://doi.org/10.1016/0006-8993(87)90306-4.

Bonhaus DW, Rigsbee LC, McNamara JO. Intranigral dynorphin-1-13 suppresses kindled seizures by a naloxone-insensitive mechanism. Brain Res. 1987 Mar 10;405(2):358–63.

Bonhaus, D. W., et al. “Intranigral dynorphin-1-13 suppresses kindled seizures by a naloxone-insensitive mechanism.” Brain Res, vol. 405, no. 2, Mar. 1987, pp. 358–63. Pubmed, doi:10.1016/0006-8993(87)90306-4.

Bonhaus DW, Rigsbee LC, McNamara JO. Intranigral dynorphin-1-13 suppresses kindled seizures by a naloxone-insensitive mechanism. Brain Res. 1987 Mar 10;405(2):358–363.