Anti-seizure and anti-epileptogenic effect of gamma-vinyl gamma-aminobutyric acid in amygdaloid kindling.

Published

Journal Article

We examined the effects of systemic administration of gamma-vinyl gamma-aminobutyric acid (GVG), a gamma-aminobutyric acid (GABA) transaminase inhibitor, on the kindling model of epilepsy in rats. GVG (1200 or 1500 mg/kg) approximately doubled the number of stimulations required for kindling development. GVG also suppressed both generalized motor seizures and electrographic after discharges in previously fully kindled animals. These results further support the idea that enhanced GABAergic neurotransmission suppresses both seizures and epileptogenesis. The results also suggest that GVG may be an effective anti-seizure and anti-epileptogenic agent in humans.

Full Text

Duke Authors

Cited Authors

  • Shin, C; Rigsbee, LC; McNamara, JO

Published In

Volume / Issue

  • 398 / 2

Start / End Page

  • 370 - 374

PubMed ID

  • 3026570

Pubmed Central ID

  • 3026570

International Standard Serial Number (ISSN)

  • 0006-8993

Language

  • eng

Conference Location

  • Netherlands