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Activity of locus coeruleus neurons in amygdala kindled rats: role in the suppression of afterdischarge.

Publication ,  Journal Article
Bonhaus, DW; McNamara, JO
Published in: Brain Res
March 24, 1987

Kindling is a model of epilepsy. The mechanisms of kindling development are unknown but may involve attenuation of noradrenergic neurotransmission. Single unit recordings, pharmacologic and lesion techniques were used to test the hypothesis that the increased seizure duration of kindled rats is the consequence of an inactivation of noradrenergic neurons in the locus coeruleus (LC). No difference was found between unkindled (naive) and kindled rats in the firing rates of recorded LC neurons either between or during seizures in the paralyzed, ventilated condition. Moreover, in naive rats, frank destruction of the LC did not lengthen seizure duration. We conclude that the lengthened seizure duration of kindled rats, in the paralyzed, ventilated conditions, is not the consequence of inactivation of the LC since the firing rate of recorded LC neurons in kindled rats was not decreased and since destruction of the LC in naive rats did not lengthen seizure duration. If attenuation of noradrenergic neurotransmission does contribute to the kindling phenomenon, then the LC is not likely to be the site at which this attenuation occurs.

Duke Scholars

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

March 24, 1987

Volume

407

Issue

1

Start / End Page

102 / 109

Location

Netherlands

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Norepinephrine
  • Neurology & Neurosurgery
  • Male
  • Locus Coeruleus
  • Kindling, Neurologic
  • Idazoxan
  • Electroencephalography
 

Citation

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ICMJE
MLA
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Bonhaus, D. W., & McNamara, J. O. (1987). Activity of locus coeruleus neurons in amygdala kindled rats: role in the suppression of afterdischarge. Brain Res, 407(1), 102–109. https://doi.org/10.1016/0006-8993(87)91223-6
Bonhaus, D. W., and J. O. McNamara. “Activity of locus coeruleus neurons in amygdala kindled rats: role in the suppression of afterdischarge.Brain Res 407, no. 1 (March 24, 1987): 102–9. https://doi.org/10.1016/0006-8993(87)91223-6.
Bonhaus, D. W., and J. O. McNamara. “Activity of locus coeruleus neurons in amygdala kindled rats: role in the suppression of afterdischarge.Brain Res, vol. 407, no. 1, Mar. 1987, pp. 102–09. Pubmed, doi:10.1016/0006-8993(87)91223-6.
Journal cover image

Published In

Brain Res

DOI

ISSN

0006-8993

Publication Date

March 24, 1987

Volume

407

Issue

1

Start / End Page

102 / 109

Location

Netherlands

Related Subject Headings

  • Seizures
  • Rats, Inbred Strains
  • Rats
  • Norepinephrine
  • Neurology & Neurosurgery
  • Male
  • Locus Coeruleus
  • Kindling, Neurologic
  • Idazoxan
  • Electroencephalography