Method of lesioning brainstem determines seizure probability.

Journal Article (Journal Article)

We examined 3 different methods of brainstem lesioning to assess their propensities to evoke seizures in the early postoperative period. Lesioning by electrolysis or microinjection of the neurotoxin, N-methyl-D,L-aspartate, caused seizures, but lesioning by thermocoagulation (radiofrequency current) did not. In paradigms in which postoperative lesion-induced seizures could confound interpretation of experimental results, the thermocoagulative method offers an important advantage.

Full Text

Duke Authors

Cited Authors

  • Silver, JM; Bonhaus, DW; McNamara, JO

Published Date

  • September 1986

Published In

Volume / Issue

  • 17 / 4

Start / End Page

  • 303 - 310

PubMed ID

  • 3537541

International Standard Serial Number (ISSN)

  • 0165-0270

Digital Object Identifier (DOI)

  • 10.1016/0165-0270(86)90131-7


  • eng

Conference Location

  • Netherlands