Changes in dynorphin, enkephalin and cholecystokinin content of hippocampus and substantia nigra after amygdala kindling.
Journal Article (Journal Article)
Amygdaloid kindling of rats produced an increase in hippocampal Met5-enkephalin-Arg6-Gly7-Leu8 and cholecystokinin immunoreactivities and simultaneously a decrease in dynorphin A1-8 content. In substantia nigra Met5-enkephalin-Arg6-Gly7-Leu8 was increased and no change was observed in dynorphin A1-8 content. These data suggest that specific alterations of neuropeptides in limbic and extrapyramidal circuits are prominent manifestations of the kindling process or kindled seizures.
Full Text
Duke Authors
Cited Authors
- Iadarola, MJ; Shin, C; McNamara, JO; Yang, HY
Published Date
- February 12, 1986
Published In
Volume / Issue
- 365 / 1
Start / End Page
- 185 - 191
PubMed ID
- 2868784
International Standard Serial Number (ISSN)
- 0006-8993
Digital Object Identifier (DOI)
- 10.1016/0006-8993(86)90738-9
Language
- eng
Conference Location
- Netherlands