Changes in dynorphin, enkephalin and cholecystokinin content of hippocampus and substantia nigra after amygdala kindling.

Journal Article (Journal Article)

Amygdaloid kindling of rats produced an increase in hippocampal Met5-enkephalin-Arg6-Gly7-Leu8 and cholecystokinin immunoreactivities and simultaneously a decrease in dynorphin A1-8 content. In substantia nigra Met5-enkephalin-Arg6-Gly7-Leu8 was increased and no change was observed in dynorphin A1-8 content. These data suggest that specific alterations of neuropeptides in limbic and extrapyramidal circuits are prominent manifestations of the kindling process or kindled seizures.

Full Text

Duke Authors

Cited Authors

  • Iadarola, MJ; Shin, C; McNamara, JO; Yang, HY

Published Date

  • February 12, 1986

Published In

Volume / Issue

  • 365 / 1

Start / End Page

  • 185 - 191

PubMed ID

  • 2868784

International Standard Serial Number (ISSN)

  • 0006-8993

Digital Object Identifier (DOI)

  • 10.1016/0006-8993(86)90738-9


  • eng

Conference Location

  • Netherlands