Comparison of the effects of diphenylbarbituric acid, phenobarbital, pentobarbital and secobarbital on GABA-mediated inhibition and benzodiazepine binding.

Journal Article (Journal Article)

We utilized biochemical and electrophysiological methods to compare the effects of anesthetic and anticonvulsant barbiturates on gamma-aminobutyric acid (GABA) receptor-coupled responses. Biochemical analysis involved barbiturate regulation of the affinity of a radiolabeled benzodiazepine for benzodiazepine receptors. The electrophysiological method involved regulation of somatic recurrent inhibition of CA1 pyramidal cells in the hippocampal slice preparation. We found that anesthetic (secobarbital and pentobarbital) but not anticonvulsant (phenobarbital and diphenylbarbituric acid) barbiturates significantly enhanced GABA receptor-coupled responses in both the biochemical and electrophysiological preparations. The results indicate that the anticonvulsant actions of barbiturates may not depend on their ability to enhance GABAergic neuronal activity.

Full Text

Duke Authors

Cited Authors

  • Iadarola, MJ; Fanelli, RJ; McNamara, JO; Wilson, WA

Published Date

  • January 1, 1985

Published In

Volume / Issue

  • 232 / 1

Start / End Page

  • 127 - 133

PubMed ID

  • 2981311

International Standard Serial Number (ISSN)

  • 0022-3565


  • eng

Conference Location

  • United States