The kindling model of epilepsy: a critical review.

Journal Article (Journal Article;Review)

Kindling is an animal model of epilepsy induced by electrical stimulation of the brain. This model has attracted the interest of many neuroscientists, in part because it involves a robust, permanent modification of brain function. This report will describe the kindling phenomenon and critically review current understanding of the underlying mechanisms. The review will carefully consider whether this model accurately reflects analogous processes in humans. The review will consider some hypotheses inspired by the kindling studies which may be relevant to human epilepsy.

Full Text

Duke Authors

Cited Authors

  • McNamara, JO; Bonhaus, DW; Shin, C; Crain, BJ; Gellman, RL; Giacchino, JL

Published Date

  • 1985

Published In

Volume / Issue

  • 1 / 4

Start / End Page

  • 341 - 391

PubMed ID

  • 3915977

International Standard Serial Number (ISSN)

  • 0742-941X


  • eng

Conference Location

  • United States