Role of neurotransmitters in seizure mechanisms in the kindling model of epilepsy.

Journal Article (Journal Article)

The molecular basis of the abnormal excitability of the kindling phenomenon is unclear. The alterations of neurotransmitters and their receptors identified in this model most likely underlie the brain's response to repetitive neuronal firing during seizures. Cellular localization of neurotransmitter receptor alterations has provided a clue to the network of brain structures responsible for kindling, a necessary first step to elucidating the basic mechanisms. Regardless of whether the molecular basis of kindling involves neurotransmitters per se, study of the role of neurotransmitters should teach many valuable lessons regarding molecular aspects of brain function.

Full Text

Duke Authors

Cited Authors

  • McNamara, JO

Published Date

  • July 1984

Published In

Volume / Issue

  • 43 / 10

Start / End Page

  • 2516 - 2520

PubMed ID

  • 6145627

International Standard Serial Number (ISSN)

  • 0014-9446


  • eng

Conference Location

  • United States