Chronic phototoxicity and aggressive squamous cell carcinoma of the skin in children and adults during treatment with voriconazole.
Journal Article (Journal Article;Multicenter Study)
BACKGROUND: Voriconazole is a broad-spectrum antifungal agent associated with photosensitivity and accelerated photoaging. A possible link with aggressive squamous cell carcinoma (SCC) has also been reported. OBJECTIVE: We sought to determine the incidence and frequency of cutaneous SCC among patients undergoing long-term treatment with voriconazole who also manifest features of chronic phototoxicity. METHODS: We conducted a retrospective review of patients who developed one or more squamous cell neoplasms during long-term treatment with voriconazole at 3 academic dermatology centers. RESULTS: A total of 51 cutaneous SCC were identified in 8 patients (median age 34.5 years, range 9-54) treated with chronic voriconazole (median duration 46.5 months, range 13-60). Underlying diagnoses included graft-versus-host disease, HIV, and Wegener granulomatosis. Signs of chronic phototoxicity and accelerated photoaging included erythema, actinic keratoses, and lentigo formation. LIMITATIONS: The retrospective nature of the study cannot determine the true population risk of SCC associated with voriconazole therapy. A prospective cohort study is needed. CONCLUSION: A high index of suspicion for photosensitivity and SCC may be warranted with chronic voriconazole use when used in the setting of concurrent immunosuppression.
Full Text
Duke Authors
Cited Authors
- Cowen, EW; Nguyen, JC; Miller, DD; McShane, D; Arron, ST; Prose, NS; Turner, ML; Fox, LP
Published Date
- January 2010
Published In
Volume / Issue
- 62 / 1
Start / End Page
- 31 - 37
PubMed ID
- 19896749
Pubmed Central ID
- PMC2815347
Electronic International Standard Serial Number (EISSN)
- 1097-6787
Digital Object Identifier (DOI)
- 10.1016/j.jaad.2009.09.033
Language
- eng
Conference Location
- United States