Skip to main content

Depression precipitated by alcohol use in patients with co-occurring bipolar and substance use disorders.

Publication ,  Journal Article
Jaffee, WB; Griffin, ML; Gallop, R; Meade, CS; Graff, F; Bender, RE; Weiss, RD
Published in: The Journal of clinical psychiatry
February 2009

Bipolar disorder and substance use disorder frequently co-occur. However, little is known about the near-term effects of substance use on bipolar disorder. Thus, the present study tests whether alcohol use precipitates depression among patients with co-occurring bipolar disorder and substance use disorder.This study uses data collected as part of 2 clinical trials (the first study was conducted from March 1999 through March 2004 and the second study was conducted from August 2003 through May 2007) of a manualized group therapy for patients with co-occurring bipolar disorder and substance dependence. One hundred fifteen participants were assessed at baseline and each month through month 8. Baseline diagnoses were made using the Structured Clinical Interview for DSM-IV, and monthly substance use and mood data were collected using the Longitudinal Interval Follow-Up Evaluation and the Addiction Severity Index. Generalized estimating equation methodology was used to analyze these longitudinal data.Our primary hypotheses were supported: days of alcohol use and an increase in days of alcohol use each significantly predicted the presence of a depressive episode in the subsequent month when controlling for current depression and current drug use.These data suggest that alcohol use in patients with bipolar disorder and substance dependence increases the risk of a depressive episode in the near term.This study draws on data generated during 2 clinical trials. One was exempt from trial registration; clinicaltrials.gov Identifier for other trial: NCT00227838.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

The Journal of clinical psychiatry

DOI

EISSN

1555-2101

ISSN

0160-6689

Publication Date

February 2009

Volume

70

Issue

2

Start / End Page

171 / 176

Related Subject Headings

  • Substance-Related Disorders
  • Statistics as Topic
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Psychotherapy, Group
  • Psychiatry
  • Middle Aged
  • Massachusetts
  • Male
  • Longitudinal Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Jaffee, W. B., Griffin, M. L., Gallop, R., Meade, C. S., Graff, F., Bender, R. E., & Weiss, R. D. (2009). Depression precipitated by alcohol use in patients with co-occurring bipolar and substance use disorders. The Journal of Clinical Psychiatry, 70(2), 171–176. https://doi.org/10.4088/jcp.08m04011
Jaffee, William B., Margaret L. Griffin, Robert Gallop, Christina S. Meade, Fiona Graff, Rachel E. Bender, and Roger D. Weiss. “Depression precipitated by alcohol use in patients with co-occurring bipolar and substance use disorders.The Journal of Clinical Psychiatry 70, no. 2 (February 2009): 171–76. https://doi.org/10.4088/jcp.08m04011.
Jaffee WB, Griffin ML, Gallop R, Meade CS, Graff F, Bender RE, et al. Depression precipitated by alcohol use in patients with co-occurring bipolar and substance use disorders. The Journal of clinical psychiatry. 2009 Feb;70(2):171–6.
Jaffee, William B., et al. “Depression precipitated by alcohol use in patients with co-occurring bipolar and substance use disorders.The Journal of Clinical Psychiatry, vol. 70, no. 2, Feb. 2009, pp. 171–76. Epmc, doi:10.4088/jcp.08m04011.
Jaffee WB, Griffin ML, Gallop R, Meade CS, Graff F, Bender RE, Weiss RD. Depression precipitated by alcohol use in patients with co-occurring bipolar and substance use disorders. The Journal of clinical psychiatry. 2009 Feb;70(2):171–176.

Published In

The Journal of clinical psychiatry

DOI

EISSN

1555-2101

ISSN

0160-6689

Publication Date

February 2009

Volume

70

Issue

2

Start / End Page

171 / 176

Related Subject Headings

  • Substance-Related Disorders
  • Statistics as Topic
  • Risk Factors
  • Randomized Controlled Trials as Topic
  • Psychotherapy, Group
  • Psychiatry
  • Middle Aged
  • Massachusetts
  • Male
  • Longitudinal Studies