Interval-timing deficits in individuals at high risk for schizophrenia.

Published

Journal Article

A duration-bisection procedure was used to study the effects of signal modality and divided attention on duration classification in participants at high genetic risk for schizophrenia (HrSz), major affective disorder (HrAff), and normal controls (NC). Participants learned short and long target durations during training and classified probe durations during test. All groups classified visual signals as shorter than equivalent duration auditory signals. However, the difference between auditory and visual signal classification was significantly larger for the HrSz group than for the NC group. We posit a model in which there is a clock rate difference between auditory and visual signals due to an attentional effect at the level of a mode switch that gates pulses into an accumulator. This attentionally mediated clock rate difference was larger for the HrSz participants than for the NC participants, resulting in a larger auditory/visual difference for the HrSz group.

Full Text

Duke Authors

Cited Authors

  • Penney, TB; Meck, WH; Roberts, SA; Gibbon, J; Erlenmeyer-Kimling, L

Published Date

  • June 2005

Published In

Volume / Issue

  • 58 / 1

Start / End Page

  • 109 - 118

PubMed ID

  • 15878731

Pubmed Central ID

  • 15878731

Electronic International Standard Serial Number (EISSN)

  • 1090-2147

International Standard Serial Number (ISSN)

  • 0278-2626

Digital Object Identifier (DOI)

  • 10.1016/j.bandc.2004.09.012

Language

  • eng