Chronic treatment with haloperidol induces deficits in working memory and feedback effects of interval timing.


Journal Article

Normal participants (n=5) having no experience with antipsychotic drugs and medicated participants (n=5) with clinical experience with chronic low doses of haloperidol (3-10 mg/day for 2-4 months) in the treatment of neuroses were evaluated for the effects of inter-trial interval (ITI) feedback on a discrete-trials peak-interval timing procedure. Feedback was presented during the ITI in the form of a histogram showing the distribution of the responses participants made on the previous trial plotted on a relative time scale. As feedback concerning the accuracy and precision of a reproduced duration (e.g., 7- and 14-s visual signals) became more remote in time, reproduced intervals gradually lengthened in duration. This rightward horizontal shift in peak time increased as a function of the probability of feedback and was enhanced by chronic treatment with haloperidol in a manner that was proportional to the duration of the signal. Our data suggest a gradual change in the underlying representation of the signal duration as a function of the remoteness of ITI feedback that is dependent upon both changes in working memory and the speed of the internal clock used to time durations in the seconds-to-minutes range.

Full Text

Cited Authors

  • Lustig, C; Meck, WH

Published Date

  • June 2005

Published In

Volume / Issue

  • 58 / 1

Start / End Page

  • 9 - 16

PubMed ID

  • 15878723

Pubmed Central ID

  • 15878723

Electronic International Standard Serial Number (EISSN)

  • 1090-2147

International Standard Serial Number (ISSN)

  • 0278-2626

Digital Object Identifier (DOI)

  • 10.1016/j.bandc.2004.09.005


  • eng