Modern uses of electron microscopy for detection of viruses.

Journal Article (Journal Article;Review)

Electron microscopy, considered by some to be an old technique, is still on the forefront of both clinical viral diagnoses and viral ultrastructure and pathogenesis studies. In the diagnostic setting, it is particularly valuable in the surveillance of emerging diseases and potential bioterrorism viruses. In the research arena, modalities such as immunoelectron microscopy, cryo-electron microscopy, and electron tomography have demonstrated how viral structural components fit together, attach to cells, assimilate during replication, and associate with the cellular machinery during replication and egression. These studies provide information for treatment and vaccine strategies.

Full Text

Duke Authors

Cited Authors

  • Goldsmith, CS; Miller, SE

Published Date

  • October 2009

Published In

Volume / Issue

  • 22 / 4

Start / End Page

  • 552 - 563

PubMed ID

  • 19822888

Pubmed Central ID

  • PMC2772359

Electronic International Standard Serial Number (EISSN)

  • 1098-6618

Digital Object Identifier (DOI)

  • 10.1128/CMR.00027-09


  • eng

Conference Location

  • United States