Immune exclusion and immnune inclusion: A new model of host-bacterial interactions in the gut
It is thought that the primary function of secretory IgA (SIgA) is, in conjunction with the mucus lining of the gut, to prevent translocation of bacteria across the epithelial barrier. In this review, we evaluate the emerging idea that SIgA and the mucus of the large bowel may actually be involved in promicrobial activity. Central to this new model is the idea that growth of bacterial biofilms in the gut may be common and is likely advantageous to the microbial community. Evidence is examined that suggests the immune system is likely involved in the maintenance of biofilms in the gut. This model of immune inclusion, if correct, likely operates in conjunction with immune exclusion, preventing bacteria from transversing the epithelial barrier. © 2004 Elsevier Inc. All rights reserved.
Everett, ML; Palestrant, D; Miller, SE; Bollinger, RR; Parker, W
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