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Mismatch repair in replication fidelity, genetic recombination, and cancer biology.

Publication ,  Journal Article
Modrich, P; Lahue, R
Published in: Annu Rev Biochem
1996

Mismatch repair stabilizes the cellular genome by correcting DNA replication errors and by blocking recombination events between divergent DNA sequences. The reaction responsible for strand-specific correction of mispaired bases has been highly conserved during evolution, and homologs of bacterial MutS and MutL, which play key roles in mismatch recognition and initiation of repair, have been identified in yeast and mammalian cells. Inactivation of genes encoding these activities results in a large increase in spontaneous mutability, and in the case of mice and men, predisposition to tumor development.

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Published In

Annu Rev Biochem

DOI

ISSN

0066-4154

Publication Date

1996

Volume

65

Start / End Page

101 / 133

Location

United States

Related Subject Headings

  • Recombination, Genetic
  • Phenotype
  • Nucleic Acid Heteroduplexes
  • Neoplasms
  • Mitosis
  • Humans
  • Escherichia coli
  • DNA Replication
  • DNA Repair
  • Biochemistry & Molecular Biology
 

Citation

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Modrich, P., & Lahue, R. (1996). Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem, 65, 101–133. https://doi.org/10.1146/annurev.bi.65.070196.000533
Modrich, P., and R. Lahue. “Mismatch repair in replication fidelity, genetic recombination, and cancer biology.Annu Rev Biochem 65 (1996): 101–33. https://doi.org/10.1146/annurev.bi.65.070196.000533.
Modrich P, Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem. 1996;65:101–33.
Modrich, P., and R. Lahue. “Mismatch repair in replication fidelity, genetic recombination, and cancer biology.Annu Rev Biochem, vol. 65, 1996, pp. 101–33. Pubmed, doi:10.1146/annurev.bi.65.070196.000533.
Modrich P, Lahue R. Mismatch repair in replication fidelity, genetic recombination, and cancer biology. Annu Rev Biochem. 1996;65:101–133.

Published In

Annu Rev Biochem

DOI

ISSN

0066-4154

Publication Date

1996

Volume

65

Start / End Page

101 / 133

Location

United States

Related Subject Headings

  • Recombination, Genetic
  • Phenotype
  • Nucleic Acid Heteroduplexes
  • Neoplasms
  • Mitosis
  • Humans
  • Escherichia coli
  • DNA Replication
  • DNA Repair
  • Biochemistry & Molecular Biology