Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.
Publication
, Journal Article
Su, SS; Modrich, P
Published in: Proc Natl Acad Sci U S A
July 1986
The Escherichia coli mutS gene product is involved in mismatch correction in this organism. We have purified a biologically active form of the 97,000 Mr protein to near homogeneity from an overproducing strain. Enzymatic and chemical protection ("footprinting") experiments have demonstrated that mutS-encoded protein specifically binds to DNA regions containing a single base-pair mismatch. The protein displayed variable affinity for the limited set of mismatches tested (G-T greater than G-A approximately equal to A-C greater than T-C).
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
July 1986
Volume
83
Issue
14
Start / End Page
5057 / 5061
Location
United States
Related Subject Headings
- Substrate Specificity
- Protein Binding
- Nucleic Acid Conformation
- Escherichia coli
- DNA-Binding Proteins
- DNA, Bacterial
- DNA Repair
- Base Composition
- Bacterial Proteins
Citation
APA
Chicago
ICMJE
MLA
NLM
Su, S. S., & Modrich, P. (1986). Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. Proc Natl Acad Sci U S A, 83(14), 5057–5061. https://doi.org/10.1073/pnas.83.14.5057
Su, S. S., and P. Modrich. “Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.” Proc Natl Acad Sci U S A 83, no. 14 (July 1986): 5057–61. https://doi.org/10.1073/pnas.83.14.5057.
Su SS, Modrich P. Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5057–61.
Su, S. S., and P. Modrich. “Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.” Proc Natl Acad Sci U S A, vol. 83, no. 14, July 1986, pp. 5057–61. Pubmed, doi:10.1073/pnas.83.14.5057.
Su SS, Modrich P. Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs. Proc Natl Acad Sci U S A. 1986 Jul;83(14):5057–5061.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
July 1986
Volume
83
Issue
14
Start / End Page
5057 / 5061
Location
United States
Related Subject Headings
- Substrate Specificity
- Protein Binding
- Nucleic Acid Conformation
- Escherichia coli
- DNA-Binding Proteins
- DNA, Bacterial
- DNA Repair
- Base Composition
- Bacterial Proteins