Escherichia coli K-12 clones that overproduce dam methylase are hypermutable.

Journal Article (Journal Article)

A strain of Escherichia coli K-12 that overproduces dam methylase 50-fold was found to be hypermutable, and mutations which resulted in loss of excess methylase activity restored mutation frequencies to wild-type levels. These results are consistent with involvement of this deoxyribonucleic acid methylase in mismatch correction.

Full Text

Duke Authors

Cited Authors

  • Herman, GE; Modrich, P

Published Date

  • January 1, 1981

Published In

Volume / Issue

  • 145 / 1

Start / End Page

  • 644 - 646

PubMed ID

  • 7007328

Pubmed Central ID

  • PMC217318

International Standard Serial Number (ISSN)

  • 0021-9193

Digital Object Identifier (DOI)

  • 10.1128/jb.145.1.644-646.1981


  • eng

Conference Location

  • United States