Escherichia coli K-12 clones that overproduce dam methylase are hypermutable.
Journal Article (Journal Article)
A strain of Escherichia coli K-12 that overproduces dam methylase 50-fold was found to be hypermutable, and mutations which resulted in loss of excess methylase activity restored mutation frequencies to wild-type levels. These results are consistent with involvement of this deoxyribonucleic acid methylase in mismatch correction.
Full Text
Duke Authors
Cited Authors
- Herman, GE; Modrich, P
Published Date
- January 1, 1981
Published In
Volume / Issue
- 145 / 1
Start / End Page
- 644 - 646
PubMed ID
- 7007328
Pubmed Central ID
- PMC217318
International Standard Serial Number (ISSN)
- 0021-9193
Digital Object Identifier (DOI)
- 10.1128/jb.145.1.644-646.1981
Language
- eng
Conference Location
- United States