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Kinetics of expansion of SIV Gag-specific CD8+ T lymphocytes following challenge of vaccinated macaques.

Publication ,  Journal Article
Abdel-Motal, UM; Gillis, J; Manson, K; Wyand, M; Montefiori, D; Stefano-Cole, K; Montelaro, RC; Altman, JD; Johnson, RP
Published in: Virology
March 15, 2005

The ability of memory T cells to mount a recall response plays a key role in the ability of vaccinated animals to contain viral challenge. In this study, we intensively monitored the expansion of SIV Gag-specific CD8+ T cells in peripheral blood and tissues of rhesus macaques vaccinated with the attenuated strain SIVmac239Delta3 and challenged with the pathogenic viruses SIVmac239 or SIVsmE660. Although all vaccinated animals were infected with challenge virus, peak levels of plasma viremia in vaccinees were decreased by 1.5 to 2 logs as compared with naive controls. Decreased levels of plasma viremia in vaccinated animals were evident as early as 7 days post-challenge, well before the expansion of SIV-specific CD8+ T cells. Expansion of SIV-specific CD8+ T cells was not observed in peripheral blood or tissues until at least 14 days after infection and did not occur in most animals until after the initial peak of viral replication. The observation that expansion of SIV-specific CD8+ T cells is delayed until 7 days or more after initial detection of viremia highlights fundamental limitations in the ability of lentivirus-specific CD8+ T cells to mediate protection against challenge.

Duke Scholars

Published In

Virology

DOI

ISSN

0042-6822

Publication Date

March 15, 2005

Volume

333

Issue

2

Start / End Page

226 / 238

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Rectum
  • RNA, Viral
  • Macaca mulatta
  • Lymph Nodes
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Abdel-Motal, U. M., Gillis, J., Manson, K., Wyand, M., Montefiori, D., Stefano-Cole, K., … Johnson, R. P. (2005). Kinetics of expansion of SIV Gag-specific CD8+ T lymphocytes following challenge of vaccinated macaques. Virology, 333(2), 226–238. https://doi.org/10.1016/j.virol.2004.12.030
Abdel-Motal, Ussama M., Jacqueline Gillis, Kelledy Manson, Michael Wyand, David Montefiori, Kelly Stefano-Cole, Ronald C. Montelaro, John D. Altman, and R Paul Johnson. “Kinetics of expansion of SIV Gag-specific CD8+ T lymphocytes following challenge of vaccinated macaques.Virology 333, no. 2 (March 15, 2005): 226–38. https://doi.org/10.1016/j.virol.2004.12.030.
Abdel-Motal UM, Gillis J, Manson K, Wyand M, Montefiori D, Stefano-Cole K, et al. Kinetics of expansion of SIV Gag-specific CD8+ T lymphocytes following challenge of vaccinated macaques. Virology. 2005 Mar 15;333(2):226–38.
Abdel-Motal, Ussama M., et al. “Kinetics of expansion of SIV Gag-specific CD8+ T lymphocytes following challenge of vaccinated macaques.Virology, vol. 333, no. 2, Mar. 2005, pp. 226–38. Pubmed, doi:10.1016/j.virol.2004.12.030.
Abdel-Motal UM, Gillis J, Manson K, Wyand M, Montefiori D, Stefano-Cole K, Montelaro RC, Altman JD, Johnson RP. Kinetics of expansion of SIV Gag-specific CD8+ T lymphocytes following challenge of vaccinated macaques. Virology. 2005 Mar 15;333(2):226–238.
Journal cover image

Published In

Virology

DOI

ISSN

0042-6822

Publication Date

March 15, 2005

Volume

333

Issue

2

Start / End Page

226 / 238

Location

United States

Related Subject Headings

  • Virology
  • Viremia
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Rectum
  • RNA, Viral
  • Macaca mulatta
  • Lymph Nodes