Postexposure immunoprophylaxis of primary isolates by an antibody to HIV receptor complex.
mAb B4 is a monoclonal antibody directed against HIV receptor complex. The antibody had broad neutralizing activity against HIV and provided postexposure prophylaxis to hu-peripheral blood leukocyte (PBL)-severe combined immunodeficient mice and chimpanzees. B4 recognized a complex receptor site for HIV on the T cell surface that includes CD4 and also may be influenced by interaction with HIV coreceptors. mAb B4 preferentially neutralized primary HIV-1 isolates compared with T cell line-adapted strains, including syncytium-inducing and non-syncytium-inducing phenotypes, representatives from HIV-1 subtypes A-G, as well as HIV-2, simian immunodeficiency virus, and chimeric simian/human immunodeficiency virus (SHIV). Neutralization was demonstrated in both pre- and postinfection models. The administration of mAb B4 after infectious challenge totally interrupted the infection of hu-PBL-severe combined immunodeficient mice by PBL-grown HIV-1 and the infection of chimpanzees by chimp-adapted HIV-1. This mode of protection suggested that the anti-HIV receptor antibody is efficacious for prophylaxis after exposure to HIV and for prevention of maternal transmission and may be an effective antiretroviral agent for treatment.
Duke Scholars
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Related Subject Headings
- Viral Plaque Assay
- Receptors, HIV
- Pan troglodytes
- Neutralization Tests
- Mice, SCID
- Mice, Inbred BALB C
- Mice
- Male
- Leukocytes
- Immunotherapy
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Viral Plaque Assay
- Receptors, HIV
- Pan troglodytes
- Neutralization Tests
- Mice, SCID
- Mice, Inbred BALB C
- Mice
- Male
- Leukocytes
- Immunotherapy