Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection.
Journal Article (Journal Article)
To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus macaques was tested. Untreated neonates became infected after oral SIV inoculation and had high viremia, and most animals developed fatal AIDS within 3 months. In contrast, SIV hyperimmune serum given subcutaneously prior to oral SIV inoculation protected 6 newborns against infection. When this SIV hyperimmune serum was given to 3 newborns 3 weeks after oral SIV inoculation, viremia was not reduced, and all 3 infants died within 3 months of age due to AIDS and immune-complex disease. These results suggest that passively acquired antihuman immunodeficiency virus (HIV) IgG may decrease perinatal HIV transmission. However, anti-HIV IgG may not impart therapeutic benefit to infants with established HIV infection.
Full Text
Duke Authors
Cited Authors
- Van Rompay, KK; Berardi, CJ; Dillard-Telm, S; Tarara, RP; Canfield, DR; Valverde, CR; Montefiori, DC; Cole, KS; Montelaro, RC; Miller, CJ; Marthas, ML
Published Date
- May 1998
Published In
Volume / Issue
- 177 / 5
Start / End Page
- 1247 - 1259
PubMed ID
- 9593009
International Standard Serial Number (ISSN)
- 0022-1899
Digital Object Identifier (DOI)
- 10.1086/515270
Language
- eng
Conference Location
- United States