Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection.

Published

Journal Article

To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus macaques was tested. Untreated neonates became infected after oral SIV inoculation and had high viremia, and most animals developed fatal AIDS within 3 months. In contrast, SIV hyperimmune serum given subcutaneously prior to oral SIV inoculation protected 6 newborns against infection. When this SIV hyperimmune serum was given to 3 newborns 3 weeks after oral SIV inoculation, viremia was not reduced, and all 3 infants died within 3 months of age due to AIDS and immune-complex disease. These results suggest that passively acquired antihuman immunodeficiency virus (HIV) IgG may decrease perinatal HIV transmission. However, anti-HIV IgG may not impart therapeutic benefit to infants with established HIV infection.

Full Text

Duke Authors

Cited Authors

  • Van Rompay, KK; Berardi, CJ; Dillard-Telm, S; Tarara, RP; Canfield, DR; Valverde, CR; Montefiori, DC; Cole, KS; Montelaro, RC; Miller, CJ; Marthas, ML

Published Date

  • May 1998

Published In

Volume / Issue

  • 177 / 5

Start / End Page

  • 1247 - 1259

PubMed ID

  • 9593009

Pubmed Central ID

  • 9593009

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/515270

Language

  • eng

Conference Location

  • United States