Human immunodeficiency virus type 1 infection despite prior immunization with a recombinant envelope vaccine regimen.

Published

Journal Article

With efforts underway to develop a preventive human immunodeficiency virus type 1 (HIV-1) vaccine, it remains unclear which immune responses are sufficient to protect against infection and whether prior HIV-1 immunity can alter the subsequent course of HIV-1 infection. We investigated these issues in the context of a volunteer who received six HIV-1LAI envelope immunizations and 10 weeks thereafter acquired HIV-1 infection through a high-risk sexual exposure. In contrast to nonvaccinated acutely infected individuals, anamnestic HIV-1-specific B- and T-cell responses appeared within 3 weeks in this individual, and neutralizing antibody preceded CD8+ cytotoxic responses. Despite an asymptomatic course and an initial low level of detectable infectious virus, a progressive CD4+ cell decline and dysfunction occurred within 2 years. Although vaccination elicited immunity to HIV-1 envelope, which was recalled upon HIV-1 exposure, it was insufficient to prevent infection and subsequent immunodeficiency.

Full Text

Duke Authors

Cited Authors

  • McElrath, MJ; Corey, L; Greenberg, PD; Matthews, TJ; Montefiori, DC; Rowen, L; Hood, L; Mullins, JI

Published Date

  • April 1996

Published In

Volume / Issue

  • 93 / 9

Start / End Page

  • 3972 - 3977

PubMed ID

  • 8633000

Pubmed Central ID

  • 8633000

Electronic International Standard Serial Number (EISSN)

  • 1091-6490

International Standard Serial Number (ISSN)

  • 0027-8424

Digital Object Identifier (DOI)

  • 10.1073/pnas.93.9.3972

Language

  • eng