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Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara.

Publication ,  Journal Article
Hirsch, VM; Fuerst, TR; Sutter, G; Carroll, MW; Yang, LC; Goldstein, S; Piatak, M; Elkins, WR; Alvord, WG; Montefiori, DC; Moss, B; Lifson, JD
Published in: J Virol
June 1996

The dynamics of plasma viremia were explored in a group of 12 simian immunodeficiency virus (SIV)-infected rhesus macaques (Macaca mulatta) that had received prior immunization with either nonrecombinant or trivalent (gag-pol, env) SIV-recombinant vaccinia viruses. Three distinct patterns of viral replication observed during and following primary viremia accounted for significant differences in survival times. High-level primary plasma viremia with subsequently increasing viremia was associated with rapid progression to AIDS (n = 2). A high-level primary plasma virus load with a transient decline and subsequent progressive increase in viremia in the post-acute phase of infection was associated with progression to AIDS within a year (n = 6). Low levels of primary plasma viremia followed by sustained restriction of virus replication were associated with maintenance of normal lymphocyte subsets and intact lymphoid architecture (n = 4), reminiscent of the profile observed in human immunodeficiency virus type 1-infected long-term nonprogressors. Three of four macaques that showed this pattern had been immunized with an SIV recombinant derived from the attenuated vaccinia virus, modified vaccinia virus Ankara. These data link the dynamics and extent of virus replication to disease course and suggest that sustained suppression of virus promotes long-term, asymptomatic survival of SIV-infected macaques. These findings also suggest that vaccine modulation of host immunity may have profound beneficial effects on the subsequent disease course, even if sterilizing immunity is not achieved.

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Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

June 1996

Volume

70

Issue

6

Start / End Page

3741 / 3752

Location

United States

Related Subject Headings

  • Virus Replication
  • Virology
  • Vaccinia virus
  • Vaccines, Synthetic
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Molecular Sequence Data
  • Macaca mulatta
  • Lymph Nodes
  • Immunization
 

Citation

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Hirsch, V. M., Fuerst, T. R., Sutter, G., Carroll, M. W., Yang, L. C., Goldstein, S., … Lifson, J. D. (1996). Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara. J Virol, 70(6), 3741–3752. https://doi.org/10.1128/JVI.70.6.3741-3752.1996
Hirsch, V. M., T. R. Fuerst, G. Sutter, M. W. Carroll, L. C. Yang, S. Goldstein, M. Piatak, et al. “Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara.J Virol 70, no. 6 (June 1996): 3741–52. https://doi.org/10.1128/JVI.70.6.3741-3752.1996.
Hirsch VM, Fuerst TR, Sutter G, Carroll MW, Yang LC, Goldstein S, Piatak M, Elkins WR, Alvord WG, Montefiori DC, Moss B, Lifson JD. Patterns of viral replication correlate with outcome in simian immunodeficiency virus (SIV)-infected macaques: effect of prior immunization with a trivalent SIV vaccine in modified vaccinia virus Ankara. J Virol. 1996 Jun;70(6):3741–3752.

Published In

J Virol

DOI

ISSN

0022-538X

Publication Date

June 1996

Volume

70

Issue

6

Start / End Page

3741 / 3752

Location

United States

Related Subject Headings

  • Virus Replication
  • Virology
  • Vaccinia virus
  • Vaccines, Synthetic
  • Simian Acquired Immunodeficiency Syndrome
  • SAIDS Vaccines
  • Molecular Sequence Data
  • Macaca mulatta
  • Lymph Nodes
  • Immunization