Antibody-dependent enhancement of SIV infection: further characterization and cross reactivity between macaque and sooty mangabey isolates.

Journal Article (Journal Article)

Plasma from four rhesus macaques (Macaca mulatta), of which two were experimentally infected with the simian immunodeficiency virus (SIV) isolate SIVmac251, one with isolate SIVsmF236, and another with a SIVsmF236 molecular clone, SIVsmH-4, enhanced SIVmac infection of MT-2 cells. In addition to SIV-positive plasma, infection-enhancement required complement, CD4, and CR2. Titers of infection-enhancing antibodies appeared to correlate with disease progression. The MT-2/SIVmac251 system should be useful in future studies of complement-mediated, antibody-dependent enhancement of macaque and sooty mangabey SIV isolates.

Full Text

Duke Authors

Cited Authors

  • Montefiori, DC; Robinson, WE; Hirsch, VM; Modliszewski, A; Mitchell, WM; Johnson, PR

Published Date

  • 1990

Published In

Volume / Issue

  • 19 / 3-4

Start / End Page

  • 269 - 278

PubMed ID

  • 2231684

International Standard Serial Number (ISSN)

  • 0047-2565


  • eng

Conference Location

  • Denmark