Discovery of thiophene inhibitors of polo-like kinase.

Journal Article (Journal Article)

The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.

Full Text

Duke Authors

Cited Authors

  • Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M

Published Date

  • February 1, 2009

Published In

Volume / Issue

  • 19 / 3

Start / End Page

  • 1018 - 1021

PubMed ID

  • 19097784

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2008.11.041


  • eng

Conference Location

  • England