Discovery of thiophene inhibitors of polo-like kinase.
Journal Article (Journal Article)
The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.
Full Text
Duke Authors
Cited Authors
- Emmitte, KA; Andrews, CW; Badiang, JG; Davis-Ward, RG; Dickson, HD; Drewry, DH; Emerson, HK; Epperly, AH; Hassler, DF; Knick, VB; Kuntz, KW; Lansing, TJ; Linn, JA; Mook, RA; Nailor, KE; Salovich, JM; Spehar, GM; Cheung, M
Published Date
- February 1, 2009
Published In
Volume / Issue
- 19 / 3
Start / End Page
- 1018 - 1021
PubMed ID
- 19097784
Electronic International Standard Serial Number (EISSN)
- 1464-3405
Digital Object Identifier (DOI)
- 10.1016/j.bmcl.2008.11.041
Language
- eng
Conference Location
- England