Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase.

Journal Article (Journal Article)

The evaluation of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines as inhibitors of the IGF-1R (IGF-IR) receptor tyrosine kinase is reported. Examples demonstrate nanomolar potencies in in vitro enzyme and mechanistic cellular assays as well as promising in vivo pharmacokinetics in rat.

Full Text

Duke Authors

Cited Authors

  • Chamberlain, SD; Wilson, JW; Deanda, F; Patnaik, S; Redman, AM; Yang, B; Shewchuk, L; Sabbatini, P; Leesnitzer, MA; Groy, A; Atkins, C; Gerding, R; Hassell, AM; Lei, H; Mook, RA; Moorthy, G; Rowand, JL; Stevens, KL; Kumar, R; Shotwell, JB

Published Date

  • January 15, 2009

Published In

Volume / Issue

  • 19 / 2

Start / End Page

  • 469 - 473

PubMed ID

  • 19056263

Electronic International Standard Serial Number (EISSN)

  • 1464-3405

Digital Object Identifier (DOI)

  • 10.1016/j.bmcl.2008.11.046


  • eng

Conference Location

  • England