Discovery of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines: potent inhibitors of the IGF-1R receptor tyrosine kinase.
Journal Article (Journal Article)
The evaluation of a series of 4,6-bis-anilino-1H-pyrrolo[2,3-d]pyrimidines as inhibitors of the IGF-1R (IGF-IR) receptor tyrosine kinase is reported. Examples demonstrate nanomolar potencies in in vitro enzyme and mechanistic cellular assays as well as promising in vivo pharmacokinetics in rat.
Full Text
Duke Authors
Cited Authors
- Chamberlain, SD; Wilson, JW; Deanda, F; Patnaik, S; Redman, AM; Yang, B; Shewchuk, L; Sabbatini, P; Leesnitzer, MA; Groy, A; Atkins, C; Gerding, R; Hassell, AM; Lei, H; Mook, RA; Moorthy, G; Rowand, JL; Stevens, KL; Kumar, R; Shotwell, JB
Published Date
- January 15, 2009
Published In
Volume / Issue
- 19 / 2
Start / End Page
- 469 - 473
PubMed ID
- 19056263
Electronic International Standard Serial Number (EISSN)
- 1464-3405
Digital Object Identifier (DOI)
- 10.1016/j.bmcl.2008.11.046
Language
- eng
Conference Location
- England