Synthesis and biological activity of a novel series of indole-derived PPARgamma agonists.

Journal Article (Journal Article)

The synthesis and structure-activity relationships of a novel series of indole 5-carboxylic acids that bind and activate peroxisome proliferator-activated receptor gamma (PPARgamma) are reported. These new analogs are selective for PPARgamma vs the other PPAR subtypes, and the most potent compounds in this series are comparable to in vitro potencies at PPARgamma reported for the thiazolidinedione-based antidiabetic drugs currently in clinical use.

Full Text

Duke Authors

Cited Authors

  • Henke, BR; Adkison, KK; Blanchard, SG; Leesnitzer, LM; Mook, RA; Plunket, KD; Ray, JA; Roberson, C; Unwalla, R; Willson, TM

Published Date

  • December 6, 1999

Published In

Volume / Issue

  • 9 / 23

Start / End Page

  • 3329 - 3334

PubMed ID

  • 10612594

International Standard Serial Number (ISSN)

  • 0960-894X

Digital Object Identifier (DOI)

  • 10.1016/s0960-894x(99)00603-4


  • eng

Conference Location

  • England