Synthesis of phenanthridin-3-one derivatives: Non-steroidal inhibitors of steroid 5-α-reductase

Journal Article (Journal Article)

A short and efficient six-step synthesis of novel phenanthridin-3-one derivatives is described. The synthesis of these derivatives is highlighted by the cyclization of a suitably placed ketone side chain with a thioiminium ion. The derivatives prepared were found to be inhibitors of human steroid 5-α-reductase. © 1995.

Full Text

Duke Authors

Cited Authors

  • Mook, RA; Lackey, K; Bennett, C

Published Date

  • June 5, 1995

Published In

Volume / Issue

  • 36 / 23

Start / End Page

  • 3969 - 3972

International Standard Serial Number (ISSN)

  • 0040-4039

Digital Object Identifier (DOI)

  • 10.1016/0040-4039(95)00690-E

Citation Source

  • Scopus