Post transplant CD8+ gammadelta T-cell lymphoma associated with human herpes virus-6 infection.

Published

Journal Article (Review)

Gammadelta T-cell lymphoma is a rare T-cell lymphoproliferative disorder that has been reported in both immunocompetent and immunocompromised persons. This report describes a forty eight year old patient who developed gammadelta T-cell lymphoma four years after undergoing living-related kidney transplantation. The lymphoma expressed CD2, CD3, CD7, CD8 and CD56, and the gammadelta T-cell receptor and did not express CD5, CD4 and the alphabeta T-cell receptor. In addition, HHV-6 was cultured from the patient's bone marrow, marking the first time that this virus has been associated with gammadelta T-cell lymphoma. Since all patients with gammadelta T-cell lymphoma described to date have responded poorly to standard combination chemotherapies, the patient was treated with the purine analogue 2-chlorodeoxyadenosine. While he responded transiently to treatment, long term remission was not achieved indicating that additional therapeutic approches still need to be developed, for the management of this disorder.

Full Text

Duke Authors

Cited Authors

  • Lin, WC; Moore, JO; Mann, KP; Traweek, ST; Smith, C

Published Date

  • April 1999

Published In

Volume / Issue

  • 33 / 3-4

Start / End Page

  • 377 - 384

PubMed ID

  • 10221519

Pubmed Central ID

  • 10221519

International Standard Serial Number (ISSN)

  • 1042-8194

Digital Object Identifier (DOI)

  • 10.3109/10428199909058439

Language

  • eng

Conference Location

  • United States