I and i antigens on normal and leukemic leukocytes.
Journal Article (Journal Article)
Human leukocyte I and i antigens were quantitated using 125I labelled purified antibodies. Binding of these antibodies to leukocytes was dependent on reduced temperature. No significant difference in antigen content was observed between normal and leukemic myeloid leukocytes. B lymphocytes bound much greater amounts of both I and i antibodies than did T lymphocytes. Neoplastic lymphoid cells bound widely divergent amounts of both antibodies with chronic lymphocytic leukemia and lymphosarcoma cell leukemia cells binding much decreased amounts compared to normal lymphocytes. Cells from patients with hairy cell leukemia bound very large quantities of these antibodies in a cold dependent fashion. These elevated levels of binding were not due to nonspecific binding of IgM.
Full Text
Duke Authors
Cited Authors
- Moore, JO; Logue, GL
Published Date
- July 1, 1978
Published In
Volume / Issue
- 42 / 1
Start / End Page
- 140 - 148
PubMed ID
- 276411
International Standard Serial Number (ISSN)
- 0008-543X
Digital Object Identifier (DOI)
- 10.1002/1097-0142(197807)42:1<140::aid-cncr2820420124>3.0.co;2-b
Language
- eng
Conference Location
- United States