I and i antigens on normal and leukemic leukocytes.

Published

Journal Article

Human leukocyte I and i antigens were quantitated using 125I labelled purified antibodies. Binding of these antibodies to leukocytes was dependent on reduced temperature. No significant difference in antigen content was observed between normal and leukemic myeloid leukocytes. B lymphocytes bound much greater amounts of both I and i antibodies than did T lymphocytes. Neoplastic lymphoid cells bound widely divergent amounts of both antibodies with chronic lymphocytic leukemia and lymphosarcoma cell leukemia cells binding much decreased amounts compared to normal lymphocytes. Cells from patients with hairy cell leukemia bound very large quantities of these antibodies in a cold dependent fashion. These elevated levels of binding were not due to nonspecific binding of IgM.

Full Text

Duke Authors

Cited Authors

  • Moore, JO; Logue, GL

Published Date

  • July 1, 1978

Published In

Volume / Issue

  • 42 / 1

Start / End Page

  • 140 - 148

PubMed ID

  • 276411

Pubmed Central ID

  • 276411

Electronic International Standard Serial Number (EISSN)

  • 1097-0142

International Standard Serial Number (ISSN)

  • 0008-543X

Digital Object Identifier (DOI)

  • 10.1002/1097-0142(197807)42:1<140::aid-cncr2820420124>3.0.co;2-b

Language

  • eng