Cholecystokinin enhances GABAergic inhibitory transmission in basolateral amygdala.

Journal Article

The neuropeptide cholecystokinin (CCK) is anxiogenic in studies of human and animal behavior. As the amygdala formation has been implicated in generation of emotional states such as anxiety, we tested the effect of CCK on spontaneous synaptic events in the basolateral amygdala (BLA) using whole cell patch recordings in rat brain slice preparation. We found that CCK increased the frequency of spontaneous inhibitory postsynaptic potentials (sIPSPs) and currents (sIPSCs). This effect was blocked by the fast sodium channel blocker tetrodotoxin (TTX), indicating that the CCK effect is likely mediated by direct excitation of GABAergic interneurons. The CCK(B) receptor subtype antagonist, CR2945, blocked the CCK effect, while CCK4, a specific CCK(B) agonist, increased sIPSC frequency. We hypothesize that these actions may underlie the anxiogenic effects of CCK observed in behavioral studies.

Full Text

Duke Authors

Cited Authors

  • Chung, L; Moore, SD

Published Date

  • December 2007

Published In

Volume / Issue

  • 41 / 6

Start / End Page

  • 453 - 463

PubMed ID

  • 17904218

International Standard Serial Number (ISSN)

  • 0143-4179

Digital Object Identifier (DOI)

  • 10.1016/j.npep.2007.08.001

Language

  • eng

Conference Location

  • Netherlands