Reduction of voltage-dependent currents by ethanol contributes to inhibition of NMDA receptor-mediated excitatory synaptic transmission.

Journal Article

Previous studies have shown inhibitory effects of EtOH on NMDA receptor-mediated synaptic transmission in several brain regions. We examined this effect of EtOH under both current clamp and voltage clamp conditions in the basolateral amygdala because of the putative role of the amygdala in mediating anxiolytic effects of EtOH. We found that EtOH reduced NMDA receptor-mediated synaptic responses. In addition, we found that NMDA receptor-mediated depolarizations could also activate a voltage-dependent regenerative potential which was also sensitive to EtOH. Pharmacological characterization of this current was consistent with a high-threshold Ca2+ current. This current also exhibited a pronounced tendency towards transient enhancement upon withdrawal of EtOH.

Full Text

Duke Authors

Cited Authors

  • Calton, JL; Wilson, WA; Moore, SD

Published Date

  • January 16, 1999

Published In

Volume / Issue

  • 816 / 1

Start / End Page

  • 142 - 148

PubMed ID

  • 9878711

International Standard Serial Number (ISSN)

  • 0006-8993

Language

  • eng

Conference Location

  • Netherlands