Neural correlates of automatic and controlled auditory processing in schizophrenia.

Journal Article (Journal Article)

Individuals with schizophrenia demonstrate impairments in selective attention and sensory processing. The authors assessed differences in brain function between 26 participants with schizophrenia and 17 comparison subjects engaged in automatic (unattended) and controlled (attended) auditory information processing using event-related functional MRI. Lower regional neural activation during automatic auditory processing in the schizophrenia group was not confined to just the temporal lobe, but also extended to prefrontal regions. Controlled auditory processing was associated with a distributed frontotemporal and subcortical dysfunction. Differences in activation between these two modes of auditory information processing were more pronounced in the comparison group than in the patient group.

Full Text

Duke Authors

Cited Authors

  • Morey, RA; Mitchell, TV; Inan, S; Lieberman, JA; Belger, A

Published Date

  • 2008

Published In

Volume / Issue

  • 20 / 4

Start / End Page

  • 419 - 430

PubMed ID

  • 19196926

Pubmed Central ID

  • PMC2709774

Electronic International Standard Serial Number (EISSN)

  • 1545-7222

Digital Object Identifier (DOI)

  • 10.1176/jnp.2008.20.4.419


  • eng

Conference Location

  • United States