Neural correlates of automatic and controlled auditory processing in schizophrenia.
Journal Article
Individuals with schizophrenia demonstrate impairments in selective attention and sensory processing. The authors assessed differences in brain function between 26 participants with schizophrenia and 17 comparison subjects engaged in automatic (unattended) and controlled (attended) auditory information processing using event-related functional MRI. Lower regional neural activation during automatic auditory processing in the schizophrenia group was not confined to just the temporal lobe, but also extended to prefrontal regions. Controlled auditory processing was associated with a distributed frontotemporal and subcortical dysfunction. Differences in activation between these two modes of auditory information processing were more pronounced in the comparison group than in the patient group.
Full Text
Duke Authors
Cited Authors
- Morey, RA; Mitchell, TV; Inan, S; Lieberman, JA; Belger, A
Published Date
- 2008
Published In
Volume / Issue
- 20 / 4
Start / End Page
- 419 - 430
PubMed ID
- 19196926
Pubmed Central ID
- 19196926
Electronic International Standard Serial Number (EISSN)
- 1545-7222
Digital Object Identifier (DOI)
- 10.1176/jnp.2008.20.4.419
Language
- eng
Conference Location
- United States