Guillain-Barre syndrome in organ and bone marrow transplant patients.


Journal Article

BACKGROUND: Guillain-Barre Syndrome (GBS) is believed to be caused by autoimmune mechanisms that are predominantly T-cell mediated. We report GBS in organ transplant patients and bone marrow transplant patients, both of whom have iatrogenically suppressed T-cell function. METHODS: We reviewed the Duke University Medical Center database from 1989-1999 for all patients who met the criteria for GBS. There were a total of 212 patients. Of these patients, two had undergone organ transplantation and two had undergone autologous bone marrow transplantation. RESULTS: Our report supports the notion that the humoral immune system is involved in the pathogenesis of GBS. Contrary to previous reports, however, functional recovery can occur without return of T-cell function. CONCLUSIONS: This suggests that in organ transplant patients, GBS may be humorally mediated and, even more importantly, responds well to treatment.

Full Text

Duke Authors

Cited Authors

  • Bulsara, KR; Baron, PW; Tuttle-Newhall, JE; Clavien, PA; Morgenlander, J

Published Date

  • April 27, 2001

Published In

Volume / Issue

  • 71 / 8

Start / End Page

  • 1169 - 1172

PubMed ID

  • 11374420

Pubmed Central ID

  • 11374420

International Standard Serial Number (ISSN)

  • 0041-1337

Digital Object Identifier (DOI)

  • 10.1097/00007890-200104270-00026


  • eng

Conference Location

  • United States