Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes.

Journal Article

DNA immunization has been investigated as a potential immunization strategy against infectious diseases and cancer. To enhance a DNA vaccine's ability to induce CTL response in vivo, we co-administered CD80 and CD86 expression cassettes along with HIV-1 immunogens. This manipulation resulted in a dramatic increase in MHC class I-restricted and CD8+ T-cell-dependent CTL responses in both mice and chimpanzees. This strategy of engineering vaccine producing cells to be more efficient T-cell activators could be an important tool for optimizing antigen-specific T-cell-mediated immune responses in the pursuit of more rationally designed vaccines and immune therapies.

Full Text

Duke Authors

Cited Authors

  • Kim, JJ; Nottingham, LK; Wilson, DM; Bagarazzi, ML; Tsai, A; Morrison, LD; Javadian, A; Chalian, AA; Agadjanyan, MG; Weiner, DB

Published Date

  • November 1998

Published In

Volume / Issue

  • 16 / 19

Start / End Page

  • 1828 - 1835

PubMed ID

  • 9795388

Pubmed Central ID

  • 9795388

International Standard Serial Number (ISSN)

  • 0264-410X

Digital Object Identifier (DOI)

  • 10.1016/s0264-410x(98)00177-7

Language

  • eng

Conference Location

  • Netherlands