Nanoscale separations combined with tandem mass spectrometry.
Journal Article (Journal Article)
High-efficiency separations of peptide mixtures, tryptic digest and other biological compounds have been achieved using nanoscale packed capillaries and capillary zone electrophoresis (CZE). The coaxial continuous-flow fast atom bombardment design is an excellent interface for coupling these separation techniques with mass spectrometry (MS). In addition, this interface is very useful for the acquisition of MS-MS data from compounds separated by nanoscale packed capillary liquid chromatography and CZE. Structurally informative daughter-ion spectra can be obtained at the low picomole to femtomole level.
- Deterding, LJ; Moseley, MA; Tomer, KB; Jorgenson, JW
- August 21, 1991
- J Chromatogr
Volume / Issue
- 554 / 1-2
Start / End Page
- 73 - 82
Digital Object Identifier (DOI)