Nanoscale separations combined with tandem mass spectrometry.

Journal Article (Journal Article)

High-efficiency separations of peptide mixtures, tryptic digest and other biological compounds have been achieved using nanoscale packed capillaries and capillary zone electrophoresis (CZE). The coaxial continuous-flow fast atom bombardment design is an excellent interface for coupling these separation techniques with mass spectrometry (MS). In addition, this interface is very useful for the acquisition of MS-MS data from compounds separated by nanoscale packed capillary liquid chromatography and CZE. Structurally informative daughter-ion spectra can be obtained at the low picomole to femtomole level.

Full Text

Duke Authors

Cited Authors

  • Deterding, LJ; Moseley, MA; Tomer, KB; Jorgenson, JW

Published Date

  • August 21, 1991

Published In

  • J Chromatogr

Volume / Issue

  • 554 / 1-2

Start / End Page

  • 73 - 82

PubMed ID

  • 1665498

Digital Object Identifier (DOI)

  • 10.1016/s0021-9673(01)88438-7


  • eng

Conference Location

  • Netherlands