Prostate-specific antigen screening and prostate cancer mortality: Implications of a randomized European study


Journal Article

Over the past two decades, prostate-specific antigen has become the primary modality for prostate cancer screening and has led to earlier detection. However, the question remains as to whether earlier detection actually leads to reductions in prostate cancer-specific mortality, especially since prostate cancer treatment can be associated with significant quality-of-life issues, including impotence and incontinence. Recently, long-term studies from Europe and the USA have demonstrated conflicting results with regard to this question. The European study demonstrated a 20% reduction in prostate cancer-specific mortality in men receiving routine screening, but concluded that 1410 men would need screening and 48 men would need treatment for prostate cancer in order to prevent one death. These findings demonstrated that prostate-specific antigen screening reduces prostate cancer-specific mortality, but reconfirmed the association of screening with a significant rate of overdiagnosis. © 2009 Future Medicine Ltd.

Full Text

Duke Authors

Cited Authors

  • Uhlman, MA; Moul, JW; Robertson, CN; Sun, L

Published Date

  • September 18, 2009

Published In

Volume / Issue

  • 5 / 3

Start / End Page

  • 281 - 286

Electronic International Standard Serial Number (EISSN)

  • 1745-5103

International Standard Serial Number (ISSN)

  • 1745-509X

Digital Object Identifier (DOI)

  • 10.2217/ahe.09.29

Citation Source

  • Scopus