Targeted prostate biopsy using statistical image analysis.

Journal Article (Journal Article)

In this paper, a method for maximizing the probability of prostate cancer detection via biopsy is presented, by combining image analysis and optimization techniques. This method consists of three major steps. First, a statistical atlas of the spatial distribution of prostate cancer is constructed from histological images obtained from radical prostatectomy specimen. Second, a probabilistic optimization framework is employed to optimize the biopsy strategy, so that the probability of cancer detection is maximized under needle placement uncertainties. Finally, the optimized biopsy strategy generated in the atlas space is mapped to a specific patient space using an automated segmentation and elastic registration method. Cross-validation experiments showed that the predictive power of the optimized biopsy strategy for cancer detection reached the 94%-96% levels for 6-7 biopsy cores, which is significantly better than standard random-systematic biopsy protocols, thereby encouraging further investigation of optimized biopsy strategies in prospective clinical studies.

Full Text

Duke Authors

Cited Authors

  • Zhan, Y; Shen, D; Zeng, J; Sun, L; Fichtinger, G; Moul, J; Davatzikos, C

Published Date

  • June 2007

Published In

Volume / Issue

  • 26 / 6

Start / End Page

  • 779 - 788

PubMed ID

  • 17679329

International Standard Serial Number (ISSN)

  • 0278-0062

Digital Object Identifier (DOI)

  • 10.1109/TMI.2006.891497


  • eng

Conference Location

  • United States