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IL28B polymorphisms and treatment of hepatitis C

Publication ,  Journal Article
Clark, PJ; Thompson, AJV; Muir, AJ
Published in: Current Hepatitis Reports
March 1, 2011

Recently, single-nucleotide polymorphisms near the IL28B gene have been identified as important in predicting treatment response and spontaneous clearance of the hepatitis C virus (HCV). In the less than 12 months since the initial genetic discoveries, our knowledge base has rapidly expanded regarding the significance of the IL28B polymorphism in a variety of clinical settings. For genotype 1 HCV infection, it is clear that IL28B genotype has an important role in the prediction of treatment-induced and spontaneous clearance. This association remains important in the HIV/HCV-coinfected population. Host genotype adds further discriminatory information in HCV genotype 2/3 infection. IL28B genotype may remain significant with direct-acting antiviral therapy, although further studies are needed for antiviral agents and novel immunotherapy. Information on IL28B genotype improves treatment prediction with standard of care and will integrate with existing pretreatment clinical factors and measures of on-treatment response. Pretreatment knowledge of sustained viral response may help to reshape treatment regimens of the future with the possibility of reducing therapy duration and improving tolerability, safety, and efficacy. © 2010 Springer Science+Business Media, LLC.

Duke Scholars

Published In

Current Hepatitis Reports

DOI

EISSN

1541-0706

ISSN

1540-3416

Publication Date

March 1, 2011

Volume

10

Issue

1

Start / End Page

70 / 78

Related Subject Headings

  • 3202 Clinical sciences
  • 1116 Medical Physiology
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Clark, P. J., Thompson, A. J. V., & Muir, A. J. (2011). IL28B polymorphisms and treatment of hepatitis C. Current Hepatitis Reports, 10(1), 70–78. https://doi.org/10.1007/s11901-010-0061-3
Clark, P. J., A. J. V. Thompson, and A. J. Muir. “IL28B polymorphisms and treatment of hepatitis C.” Current Hepatitis Reports 10, no. 1 (March 1, 2011): 70–78. https://doi.org/10.1007/s11901-010-0061-3.
Clark PJ, Thompson AJV, Muir AJ. IL28B polymorphisms and treatment of hepatitis C. Current Hepatitis Reports. 2011 Mar 1;10(1):70–8.
Clark, P. J., et al. “IL28B polymorphisms and treatment of hepatitis C.” Current Hepatitis Reports, vol. 10, no. 1, Mar. 2011, pp. 70–78. Scopus, doi:10.1007/s11901-010-0061-3.
Clark PJ, Thompson AJV, Muir AJ. IL28B polymorphisms and treatment of hepatitis C. Current Hepatitis Reports. 2011 Mar 1;10(1):70–78.
Journal cover image

Published In

Current Hepatitis Reports

DOI

EISSN

1541-0706

ISSN

1540-3416

Publication Date

March 1, 2011

Volume

10

Issue

1

Start / End Page

70 / 78

Related Subject Headings

  • 3202 Clinical sciences
  • 1116 Medical Physiology
  • 1103 Clinical Sciences