Hepato-biliary late effects in survivors of childhood and adolescent cancer: a report from the Children's Oncology Group.

Journal Article (Journal Article;Review)

Curative therapy for childhood and adolescent cancer translates to 1 in 640 young adults being a survivor of cancer. Although acute hepato-biliary toxicity occurs commonly during pediatric cancer therapy, the impact of antineoplastic therapy on long-term liver health in childhood/adolescent cancer survivors is unknown. This article reviews the medical literature on late liver dysfunction following treatment for childhood/adolescent cancer. We also outline the Children's Oncology Group (COG) guidelines for screening and follow-up of hepato-biliary sequelae. As the population of survivors grow and age, vigilance for risks to hepatic health needs to continue based on specific exposures during curative cancer therapy.

Full Text

Duke Authors

Cited Authors

  • Castellino, S; Muir, A; Shah, A; Shope, S; McMullen, K; Ruble, K; Barber, A; Davidoff, A; Hudson, MM

Published Date

  • May 2010

Published In

Volume / Issue

  • 54 / 5

Start / End Page

  • 663 - 669

PubMed ID

  • 19890896

Pubmed Central ID

  • PMC2838980

Electronic International Standard Serial Number (EISSN)

  • 1545-5017

Digital Object Identifier (DOI)

  • 10.1002/pbc.22265


  • eng

Conference Location

  • United States