The biology of tobacco and nicotine: bench to bedside.

Journal Article

Strong epidemiologic evidence links smoking and cancer. An increased understanding of the molecular biology of tobacco-related cancers could advance progress toward improving smoking cessation and patient management. Knowledge gaps between tobacco addiction, tumorigenesis, and cancer brought an interdisciplinary group of investigators together to discuss "The Biology of Nicotine and Tobacco: Bench to Bedside." Presentations on the signaling pathways and pathogenesis in tobacco-related cancers, mouse models of addiction, imaging and regulation of nicotinic receptors, the genetic basis for tobacco carcinogenesis and development of lung cancer, and molecular mechanisms of carcinogenesis were heard. Importantly, new opportunities to use molecular biology to identify and abrogate tobacco-mediated carcinogenesis and to identify high-risk individuals were recognized.

Full Text

Duke Authors

Cited Authors

  • Dennis, PA; Van Waes, C; Gutkind, JS; Kellar, KJ; Vinson, C; Mukhin, AG; Spitz, MR; Bailey-Wilson, JE; Yeh, GC; Anderson, LM; Wiest, JS

Published Date

  • April 2005

Published In

Volume / Issue

  • 14 / 4

Start / End Page

  • 764 - 767

PubMed ID

  • 15824140

Pubmed Central ID

  • PMC3459058

International Standard Serial Number (ISSN)

  • 1055-9965

Digital Object Identifier (DOI)

  • 10.1158/1055-9965.EPI-04-0652


  • eng

Conference Location

  • United States