N-methyl-D-aspartate receptor binding in brains of rats at different ages.

Journal Article (Journal Article)

Potential age differences in N-methyl-D-aspartate (NMDA) receptor binding were evaluated in rat brain using [3H]dizocilpine and [3H]D,L-(E)-2-amino-4-propyl-5-phosphono-3-pentanoic acid (CGP 39653) as the radioligands. Neither [3H]dizocilpine nor [3H]CGP 39653 binding in hippocampus revealed any age difference (7 vs. 23-25 months) in Bmax or Kd. High-affinity [3H]dizocilpine binding showed a developmental increase (8 vs. 2 months) in hippocampus but not in frontal cortex. No senescence-related change (25 vs. 8 months) was observed in either region. The lack of senescence-related differences in these biochemical markers does not preclude the possibility of functional changes in the NMDA receptor with aging.

Full Text

Duke Authors

Cited Authors

  • Shimada, A; Mukhin, A; Ingram, DK; London, ED

Published Date

  • 1997

Published In

Volume / Issue

  • 18 / 3

Start / End Page

  • 329 - 333

PubMed ID

  • 9263199

International Standard Serial Number (ISSN)

  • 0197-4580

Digital Object Identifier (DOI)

  • 10.1016/s0197-4580(97)80315-6


  • eng

Conference Location

  • United States