mGluR modulation of post-traumatic neuronal death: role of NMDA receptors.

Journal Article (Journal Article)

The potential interaction between group I metabotropic glutamate receptors (mGluR) and NMDA receptors in mediating of post-traumatic neuronal death was studied using an in vitro trauma model. Treatment with group I mGluR antagonists provided significant neuroprotection either in the presence or absence of an NMDA receptor antagonist. In contrast, treatment with a group I mGluR agonist alone significantly exacerbated injury; this exacerbation was significantly, but incompletely, reduced in the presence of an NMDA receptor antagonist. These findings are consistent with the conclusion that the effects of group I mGluR activation on post-traumatic cell death are mediated only in part through NMDA receptor modulation and suggest that group I mGluR antagonists may have important therapeutic potential.

Full Text

Duke Authors

Cited Authors

  • Mukhin, AG; Ivanova, SA; Faden, AI

Published Date

  • July 28, 1997

Published In

Volume / Issue

  • 8 / 11

Start / End Page

  • 2561 - 2566

PubMed ID

  • 9261827

International Standard Serial Number (ISSN)

  • 0959-4965

Digital Object Identifier (DOI)

  • 10.1097/00001756-199707280-00028


  • eng

Conference Location

  • England