[Endogenous inhibitors of the specific binding of benzodiazepines in the cerebral cortex].

Journal Article (English Abstract;Journal Article)

The nature of inhibitors of [3H]-diazepam (D) specific binding (SB) was studied in 2 fractions of acidic extract from bovine brain cortex. Preparative high-performance liquid chromatography (HPLC), mass spectrometry, UV and IR techniques identified hypoxanthine and inosine as inhibitors of SB D. These substances may participate in the neuronal activity control which is in part mediated by the benzodiazepine receptors.

Full Text

Duke Authors

Cited Authors

  • Kladnitskiń≠, AV; Mukhin, AG

Published Date

  • 1988

Published In

Volume / Issue

  • 88 / 12

Start / End Page

  • 98 - 103

PubMed ID

  • 2907707

International Standard Serial Number (ISSN)

  • 0044-4588

Language

  • rus

Conference Location

  • Russia (Federation)