[Endogenous inhibitors of specific benzodiazepine binding in the cerebral cortex of the bull].

Journal Article (English Abstract;Journal Article)

Chromatography of an acidic extract from bovine brain cortex on a Sephadex G-10 column demonstrated 7 fractions capable of inhibiting specific binding of 3H-diazepam to brain cortex membranes. It was established by ultrafiltration that the molecular weights of the inhibitors were not higher than 5000 dalton. Scatchard analysis of 4 main fractions has revealed a type of inhibition similar to the competitive one. Activity of all the fractions remained unchanged after pronase treatment.

Full Text

Duke Authors

Cited Authors

  • Kladnitskiń≠, AV; Mukhin, AG

Published Date

  • October 1, 1984

Published In

Volume / Issue

  • 98 / 10

Start / End Page

  • 439 - 441

PubMed ID

  • 6149775

International Standard Serial Number (ISSN)

  • 0365-9615

Language

  • rus

Conference Location

  • Russia (Federation)